Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms

  title={Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms},
  author={Lili A. Barouch and Robert W. Harrison and Michel W. Skaf and Gisele O. Rosas and Thomas P. Cappola and Zoulficar A. Kobeissi and Ion A. Hobai and Christopher A. Lemmon and Arthur L. Burnett and Brian O'Rourke and E. Ren{\'e} Rodr{\'i}guez and Paul Lee Huang and Joao A. C. Lima and Dan E. Berkowitz and Joshua M Hare},
Subcellular localization of nitric oxide (NO) synthases with effector molecules is an important regulatory mechanism for NO signalling. In the heart, NO inhibits L-type Ca2+ channels but stimulates sarcoplasmic reticulum (SR) Ca2+ release, leading to variable effects on myocardial contractility. Here we show that spatial confinement of specific NO synthase isoforms regulates this process. Endothelial NO synthase (NOS3) localizes to caveolae, where compartmentalization with β-adrenergic… CONTINUE READING
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