Nitric oxide regulates monocyte chemotactic protein-1.

  title={Nitric oxide regulates monocyte chemotactic protein-1.},
  author={Philip S. Tsao and Beverly Yiyao Wang and Robison Buitrago and John Y-J Shyy and John P Cooke},
  volume={96 3},
BACKGROUND Monocyte chemotactic protein-1 (MCP-1) is a 76-amino-acid chemokine thought to be the major chemotactic factor for monocytes. We and others have demonstrated that NO inhibits monocyte-endothelial cell interactions and atherogenesis. We hypothesize that the antiatherogenic effect of NO may be due in part to its inhibition of MCP-1 expression. METHODS AND RESULTS Smooth muscle cells (SMCs) were isolated from normal rabbit aortas by the explant method. Cells were then exposed to LPS… CONTINUE READING