Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways.

  title={Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways.},
  author={Lisa A. Ridnour and Alisha N. Windhausen and Jeffrey S. Isenberg and Nolan Yeung and Douglas D. Thomas and Michael P Vitek and David D. Roberts and David A Wink},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 43},
Matrix metalloproteinases (MMPs) are of central importance in the proteolytic remodeling of matrix and the generation of biologically active molecules. MMPs are distinguished by a conserved catalytic domain containing a zinc ion, as well as a prodomain that regulates enzyme activation by modulation of a cysteine residue within that domain. Because nitric oxide (NO) and derived reactive nitrogen species target zinc ions and cysteine thiols, we assessed the ability of NO to regulate MMPs. A dose… CONTINUE READING
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