Nitric oxide regulates interleukin 1 bioactivity released from murine macrophages.

@article{Hill1996NitricOR,
  title={Nitric oxide regulates interleukin 1 bioactivity released from murine macrophages.},
  author={Jeanette R Hill and John A Corbett and Guim Kwon and Connie A. Marshall and Michael L. McDaniel},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 37},
  pages={22672-8}
}
The bioactivity of interleukin-1 (IL-1), a major proinflammatory cytokine, can be modulated by a variety of factors including inhibitors of IL-1 production and release and receptor blockade by IL-1 receptor antagonist and by binding to nonsignaling soluble receptors. This study demonstrates that the free radical nitric oxide (NO) is also a regulator of IL-1 bioactivity. Lipopolysaccharide-activated murine macrophage RAW264.7 cells, and lipopolysaccharide plus interferon-gamma-activated murine… CONTINUE READING

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