Nitric oxide regulates human sperm capacitation and protein-tyrosine phosphorylation in vitro.

@article{Herrero1999NitricOR,
  title={Nitric oxide regulates human sperm capacitation and protein-tyrosine phosphorylation in vitro.},
  author={Mar{\'i}a Bel{\'e}n Herrero and Eve de Lamirande and Claude Gagnon},
  journal={Biology of reproduction},
  year={1999},
  volume={61 3},
  pages={575-81}
}
The aim of the present study was to investigate whether the generation of nitric oxide by human spermatozoa is associated with human sperm capacitation and with the tyrosine phosphorylation of sperm proteins. Human spermatozoa were capacitated in the presence or absence of nitric oxide-releasing compounds or nitric oxide synthase inhibitors, and then the percentage of acrosome loss induced by human follicular fluid or by calcium ionophore was determined. The presence of the nitric oxide… CONTINUE READING