Nitric oxide regulates endotoxin-induced TNF-alpha production by human neutrophils.

@article{Dervort1994NitricOR,
  title={Nitric oxide regulates endotoxin-induced TNF-alpha production by human neutrophils.},
  author={A L Van Dervort and L Yan and Patricia Madara and J. Perren Cobb and Robert A. Wesley and Christina Corriveau and M M Tropea and Robert L Danner},
  journal={Journal of immunology},
  year={1994},
  volume={152 8},
  pages={4102-9}
}
We studied the effect of nitric oxide on LPS-induced TNF-alpha production by human neutrophils. Human neutrophils exposed to LPS and IFN-gamma did not show measurable increases in intracellular cyclic GMP (cGMP). However, cGMP increased upto 30-fold (p < 0.01) in neutrophils incubated with both sodium nitroprusside (SNP), an exogenous source of nitric oxide, and N-acetylcysteine (NAC), which increases the bioavailability of nitric oxide; this increase indicates that neutrophils contain a nitric… CONTINUE READING

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