Nitric oxide reduces endothelial expression of intercellular adhesion molecule (ICAM)-1.

@article{Biffl1996NitricOR,
  title={Nitric oxide reduces endothelial expression of intercellular adhesion molecule (ICAM)-1.},
  author={Walter L. Biffl and Ernest Eugene Moore and Fredrick Moore and Carlton C. Barnett},
  journal={The Journal of surgical research},
  year={1996},
  volume={63 1},
  pages={
          328-32
        }
}
Nitric oxide (NO.) has proven effective in improving oxygenation and reducing pulmonary hypertension in the acute respiratory distress syndrome (ARDS), but the precise mechanism remains unclear. NO. has been shown to reduce leukocyte-endothelial adhesion, attenuate neutrophil (PMN) sequestration, and protect endothelium from an inflammatory insult. Intercellular adhesion molecule (ICAM)-1 is a pivotal regulator of PMN-endothelial adhesion and, thus, a critical mediator of PMN cytotoxicity… CONTINUE READING
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