Nitric oxide receptor soluble guanylyl cyclase undergoes splicing regulation in differentiating human embryonic cells.

@article{Sharin2011NitricOR,
  title={Nitric oxide receptor soluble guanylyl cyclase undergoes splicing regulation in differentiating human embryonic cells.},
  author={Vladislav G Sharin and Kalpana Mujoo and Alexander Ya Kots and Emil Martin and Ferid Murad and Iraida G. Sharina},
  journal={Stem cells and development},
  year={2011},
  volume={20 7},
  pages={1287-93}
}
Nitric oxide (NO), an important mediator molecule in mammalian physiology, initiates a number of signaling mechanisms by activating the enzyme soluble guanylyl cyclase (sGC). Recently, a new role for NO/cyclic guanosine monophosphate signaling in embryonic development and cell differentiation has emerged. The changes in expression of NO synthase isoforms and various sGC subunits has been demonstrated during human and mouse embryonic stem (ES) cells differentiation. Previously, our laboratory… CONTINUE READING

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