Nitric oxide promotes proliferation and plasminogen activator production by coronary venular endothelium through endogenous bFGF.

@article{Ziche1997NitricOP,
  title={Nitric oxide promotes proliferation and plasminogen activator production by coronary venular endothelium through endogenous bFGF.},
  author={Marina Ziche and Astrid Parenti and Fabrizio Ledda and Patrizia Dell'era and Harris J. Granger and Carlo A. Maggi and Marco Presta},
  journal={Circulation research},
  year={1997},
  volume={80 6},
  pages={845-52}
}
We reported previously that NO is responsible for the angiogenesis produced by endothelium-dependent vasodilating peptides. To investigate the mechanisms by which NO controls angiogenesis, NO was assessed for the ability to affect cell proliferation and upregulation of urokinase-type plasminogen activator (uPA) induced by basic fibroblast growth factor (bFGF) when added exogenously to or when produced endogenously by coronary venular endothelial cells (CVECs). The treatment of the cells with… CONTINUE READING