Nitric oxide production is enhanced in rat brain before oxygen-induced convulsions.

@article{Demchenko2001NitricOP,
  title={Nitric oxide production is enhanced in rat brain before oxygen-induced convulsions.},
  author={Ivan T Demchenko and Albert E. Boso and A. Richard Whorton and Claude A. Piantadosi},
  journal={Brain research},
  year={2001},
  volume={917 2},
  pages={253-61}
}
Central nervous system oxygen toxicity (CNS O2 toxicity) is preceded by release of hyperoxic vasoconstriction, which increases regional cerebral blood flow (rCBF). These increases in rCBF precede the onset of O2-induced convulsions. We have tested the hypothesis that hyperbaric oxygen (HBO2) stimulates NO* production in the brain that leads to hyperemia and anticipates electrical signs of neurotoxicity. We measured rCBF and EEG responses in rats exposed at 4 to 6 atmospheres (ATA) of HBO2 and… CONTINUE READING

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