Nitric oxide production is a proximal signaling event controlling exercise-induced mRNA expression in human skeletal muscle.

@article{Steensberg2007NitricOP,
  title={Nitric oxide production is a proximal signaling event controlling exercise-induced mRNA expression in human skeletal muscle.},
  author={Adam Steensberg and Charlotte Keller and Thore Hillig and Christian Fr\osig and J\orgen F P Wojtaszewski and Bente Klarlund Pedersen and Henriette Pilegaard and Mikael Sander},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2007},
  volume={21 11},
  pages={2683-94}
}
Previous studies have described the magnitude and time course by which several genes are regulated within exercising skeletal muscle. These include interleukin-6 (IL-6), interleukin-8 (IL-8), heme oxygenase-1 (HO-1), and heat shock protein-72 (HSP72), which are involved in secondary signaling and preservation of intracellular environment. However, the primary signaling mechanisms coupling contraction to transcription are unknown. We hypothesized that exercise-induced nitric oxide (NO… CONTINUE READING

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