Nitric oxide production in the perifornical-lateral hypothalamic area and its influences on the modulation of perifornical-lateral hypothalamic area neurons.

@article{Kostin2011NitricOP,
  title={Nitric oxide production in the perifornical-lateral hypothalamic area and its influences on the modulation of perifornical-lateral hypothalamic area neurons.},
  author={Andrey M. Kostin and Seema Rai and Sunil Kumar and Ronald Szymusiak and Dennis McGinty and Md Noor Alam},
  journal={Neuroscience},
  year={2011},
  volume={179},
  pages={159-69}
}
The perifornical-lateral hypothalamic area (PF-LHA) is a major wake-promoting structure. It predominantly contains neurons that are active during behavioral and cortical activation. PF-LHA stimulation produces arousal and PF-LHA lesions produce somnolence. Nitric oxide (NO) is a gaseous neurotransmitter that has been implicated in the regulation of multiple pathological and physiological processes including the regulation of sleep. NO levels are higher in the cortex and in the basal forebrain… CONTINUE READING