Nitric oxide production in the hypoxic lung.

@article{Cras2001NitricOP,
  title={Nitric oxide production in the hypoxic lung.},
  author={Timothy D Le Cras and Ivan F. McMurtry},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2001},
  volume={280 4},
  pages={L575-82}
}
Nitric oxide (NO) is a potent vasodilator and inhibitor of vascular remodeling. Reduced NO production has been implicated in the pathophysiology of pulmonary hypertension, with endothelial NO synthase (NOS) knockout mice showing an increased risk for pulmonary hypertension. Because molecular oxygen (O2) is an essential substrate for NO synthesis by the NOSs and biochemical studies using purified NOS isoforms have estimated the Michaelis-Menten constant values for O2 to be in the physiological… CONTINUE READING

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