Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.

@article{Papapetropoulos1997NitricOP,
  title={Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.},
  author={Andreas Papapetropoulos and Guillermo Garc{\'i}a-Carde{\~n}a and Joseph A. Madri and William C Sessa},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={100 12},
  pages={3131-9}
}
Vascular endothelial growth factor (VEGF) is a regulator of vasculogenesis and angiogenesis. To investigate the role of nitric oxide (NO) in VEGF-induced proliferation and in vitro angiogenesis, human umbilical vein endothelial cells (HUVEC) were used. VEGF stimulated the growth of HUVEC in an NO-dependent manner. In addition, VEGF promoted the NO-dependent formation of network-like structures in HUVEC cultured in three dimensional (3D) collagen gels. Exposure of cells to VEGF led to a… CONTINUE READING
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Vascular endothelial growth factor/vascular permeability factor augments nitric oxide release from quiescent rabbit and human vascular endothelium

  • R. van der Zee, T. Murohara, +4 authors J.M
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