Nitric oxide production by peritoneal macrophages from aged rats: A short term and direct modulation by citrulline.

@article{Breuillard2017NitricOP,
  title={Nitric oxide production by peritoneal macrophages from aged rats: A short term and direct modulation by citrulline.},
  author={C. Breuillard and E. Curis and S. Le Pl{\'e}nier and L. Cynober and C. Moinard},
  journal={Biochimie},
  year={2017},
  volume={133},
  pages={
          66-73
        }
}
Citrulline has anti-inflammatory properties and exerts beneficial effects on various impaired functions in aging. However, there are few data on citrulline action on immune function in aged populations. The objective of the study was to evaluate citrulline ability, after in vivo and in vitro administration, to modulate macrophage functions in aged rats and the possible pathways involved. Twenty-one-month-old Sprague-Dawley rats (n = 27) received a citrulline supplementation at 5 g/kg/d for 5… Expand
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