Nitric oxide production by monocytes in alcoholic liver disease.

  title={Nitric oxide production by monocytes in alcoholic liver disease.},
  author={N C Hunt and R Goldin},
  journal={Journal of hepatology},
  volume={14 2-3},
Nitric oxide, initially described as an endothelial-derived relaxing factor, has recently been recognised as a mediator of macrophage function. We have studied the production of nitric oxide by peripheral blood monocytes from both normal volunteers and alcoholics. This was measured indirectly by assessing nitrite formation. Normal monocytes were found to produce a basal level of nitrite, which could be stimulated more than 6-fold using endotoxin. This effect was abrogated by the addition of… CONTINUE READING