Nitric oxide production by activated human neutrophils exposed to sodium azide and hydroxylamine: the role of oxygen radicals.

@article{Markert1994NitricOP,
  title={Nitric oxide production by activated human neutrophils exposed to sodium azide and hydroxylamine: the role of oxygen radicals.},
  author={Mich{\`e}le Markert and B Carnal and Jacques Mau{\"e}l},
  journal={Biochemical and biophysical research communications},
  year={1994},
  volume={199 3},
  pages={1245-9}
}
The occurrence of a nitric oxide-generating system in human neutrophils has been controversial and the detection of nitric oxide rendered more difficult due to the capacity of oxygen radicals and other compounds to scavenge this molecule. Our results demonstrate that human neutrophils, when stimulated by adherence or by phorbol myristate acetate generate nitrite upon exposure to NaN3 or hydroxylamine. NaN3-dependent nitrite production was further increased by the addition of superoxide… CONTINUE READING

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