Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides.

@article{Sakurai1995NitricOP,
  title={Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides.},
  author={Hiromu Sakurai and Hitoshi Kohsaka and Monica L Liu and Hiroyuki Higashiyama and Yukio Hirata and Katsue Kanno and Ichiro Saito and Nobuyuki Miyasaka},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={96 5},
  pages={2357-63}
}
In this study, we have identified the source of nitric oxide (NO) produced in the human inflammatory joints by analyzing expression of inducible NO synthase. In ex vivo organ cultures, both inflammatory synovium and cartilage from patients with rheumatoid arthritis produced NO. The NO production was suppressed by NG-monomethyl-L-arginine, an inhibitor of NO synthase. The amount of NO produced by the synovium correlated with the proportion of CD14+ cells in the corresponding tissue (r = 0.8, P… CONTINUE READING

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