Nitric oxide-producing polyurethanes.

  title={Nitric oxide-producing polyurethanes.},
  author={Ho-wook Jun and Lakeshia J. Taite and Jennifer L West},
  volume={6 2},
Thrombus formation and eventual intimal hyperplasia are the leading causes of small-diameter synthetic vascular graft failure. To combat these issues, we have incorporated a diazeniumdiolate-modified nitric oxide (NO)-producing peptide into a polyurethane to improve the thromboresistance of this biocompatible polymer. NO production by polyurethane films occurred for approximately 2 months under physiological conditions, and mechanical properties of the material were suitable for vascular graft… CONTINUE READING
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