Nitric oxide produces HLA-G nitration and induces metalloprotease-dependent shedding creating a tolerogenic milieu.

@article{DazLagares2009NitricOP,
  title={Nitric oxide produces HLA-G nitration and induces metalloprotease-dependent shedding creating a tolerogenic milieu.},
  author={Angel D{\'i}az-Lagares and Estibaliz Alegre and Joel Lemaoult and Edgardo D. Carosella and {\'A}lvaro Gonzalez},
  journal={Immunology},
  year={2009},
  volume={126 3},
  pages={436-45}
}
Human leucocyte antigen G (HLA-G) is a tolerogenic molecule that protects the fetus from maternal immune attack, may favour tumoral immunoescape and is up-regulated in viral and inflammatory diseases. The aim of this work was to discover if nitric oxide (NO) could affect HLA-G expression or function because NO is an important modulator of innate and adaptive immunity. For this purpose HLA-G expression and function were analysed following treatment with a NO donor or a peroxynitrite donor in… CONTINUE READING

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HLA-G expression

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