Nitric oxide prevents oxidative damage produced by tert-butyl hydroperoxide in erythroleukemia cells via nitrosylation of heme and non-heme iron. Electron paramagnetic resonance evidence.

@article{Gorbunov1997NitricOP,
  title={Nitric oxide prevents oxidative damage produced by tert-butyl hydroperoxide in erythroleukemia cells via nitrosylation of heme and non-heme iron. Electron paramagnetic resonance evidence.},
  author={Nikolai V Gorbunov and Jack C. Yalowich and Arunasri Gaddam and P Thampatty and Vladimir B. Ritov and Elena R. Kisin and Nabil M. Elsayed and Valerian E Kagan},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 19},
  pages={12328-41}
}
We studied protective effects of NO against tert-butylhydroperoxide (t-BuOOH)-induced oxidations in a subline of human erythroleukemia K562 cells with different intracellular hemoglobin (Hb) concentrations. t-BuOOH-induced formation of oxoferryl-Hb-derived free radical species in cells was demonstrated by low temperature EPR spectroscopy. Intensity of the signals was proportional to Hb concentrations and was correlated with cell viability. Peroxidation of phosphatidylcholine… CONTINUE READING

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