Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes.

  title={Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes.},
  author={Deepak Chandra and Elias B. Jackson and Kota V Ramana and Rocky Kelley and Satish K. Srivastava and Aruni Bhatnagar},
  volume={51 10},
Increased glucose utilization by aldose reductase (AR) has been implicated in the development of diabetes complications. However, the mechanisms that regulate AR during diabetes remain unknown. Herein we report that several nitric oxide (NO) donors prevent ex vivo synthesis of sorbitol in erythrocytes obtained from diabetic or nondiabetic rats. Compared with erythrocytes of nondiabetic rats, the AR activity in the erythrocytes of diabetic rats was less sensitive to inhibition by NO donors or by… CONTINUE READING


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