Nitric oxide potentiates hydrogen peroxide-induced killing of Escherichia coli

@article{Pacelli1995NitricOP,
  title={Nitric oxide potentiates hydrogen peroxide-induced killing of Escherichia coli},
  author={Roberto Pacelli and David A Wink and John A. Cook and Murali Cherukuri Krishna and William G Degraff and Norman W. Friedman and Maria G Tsokos and Amram Samuni and James B. Mitchell},
  journal={The Journal of Experimental Medicine},
  year={1995},
  volume={182},
  pages={1469 - 1479}
}
Previously, we reported that nitric oxide (NO) provides significant protection to mammalian cells from the cytotoxic effects of hydrogen peroxide (H2O2). Murine neutrophils and activated macrophages, however, produce NO, H2O2, and other reactive oxygen species to kill microorganisms, which suggests a paradox. In this study, we treated bacteria (Escherichia coli) with NO and H2O2 for 30 min and found that exposure to NO resulted in minimal toxicity, but greatly potentiated (up to 1,000-fold… CONTINUE READING
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