Nitric oxide pathway, Ca2+, and serotonin content in platelets from patients suffering from chronic daily headache.

Abstract

An alteration in serotonin concentration has been found in patients with chronic headache caused by abuse of analgesic substances as well as an up-regulation of 5HT2 platelet receptors, which has been correlated with chronicization of the headache. In a previous study we demonstrated an increase in L-arginine/nitric oxide (NO) pathway activity in platelets… (More)

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