Nitric oxide participates in the regulation of pancreatic acinar cell secretion.

@article{Wrenn1994NitricOP,
  title={Nitric oxide participates in the regulation of pancreatic acinar cell secretion.},
  author={Robert W. Wrenn and Mark G. Currie and Lee E. Herman},
  journal={Life sciences},
  year={1994},
  volume={55 7},
  pages={
          511-8
        }
}
The role of nitric oxide (NO) in the regulation of exocrine secretion was investigated in isolated rat pancreatic acini. NO synthase activity was detected in the extract of acini and purified by ion-exchange and 2',5'-ADP agarose chromatographies. Enzyme activity was determined by conversion of 3H-arginine to 3H-citrulline, by measurement of nitrite (a breakdown product of NO) and by generation of cyclic GMP. Treatment of acini with L-arginine increased nitrite as well as cyclic GMP and amylase… CONTINUE READING