Nitric oxide partially controls Coxiella burnetii phase II infection in mouse primary macrophages.

@article{Zamboni2003NitricOP,
  title={Nitric oxide partially controls Coxiella burnetii phase II infection in mouse primary macrophages.},
  author={Dario S Zamboni and Michel Rabinovitch},
  journal={Infection and immunity},
  year={2003},
  volume={71 3},
  pages={
          1225-33
        }
}
In most primary or continuous cell cultures infected with the Q-fever agent Coxiella burnetii, bacteria are typically sheltered in phagolysosome-like, large replicative vacuoles (LRVs). We recently reported that only a small proportion of mouse peritoneal macrophages (PMPhi) infected with a nonvirulent, phase II strain of C. burnetii developed LRVs and that their relative bacterial load increased only slowly. In the majority of infected PMPhi, the bacteria were confined to the small vesicles… CONTINUE READING

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