Nitric oxide modulates vascular inflammation and intimal hyperplasia in insulin resistance and the metabolic syndrome.

@article{Barbato2005NitricOM,
  title={Nitric oxide modulates vascular inflammation and intimal hyperplasia in insulin resistance and the metabolic syndrome.},
  author={Joel E Barbato and Brian S Zuckerbraun and Marcus Overhaus and Kathleen G. Raman and Edith E. Tzeng},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={289 1},
  pages={H228-36}
}
Type 2 diabetes mellitus (DM) and the metabolic syndrome, both characterized by insulin resistance, are associated with an accelerated form of atherosclerotic vascular disease and poor outcomes following vascular interventions. These vascular effects are thought to stem from a heightened inflammatory environment and reduced bioavailability of nitric oxide (NO). To better understand this process, we characterized the vascular injury response in the obese Zucker rat by examining the expression of… CONTINUE READING