Nitric oxide modulates the catalytic activity of myeloperoxidase.

@article{AbuSoud2000NitricOM,
  title={Nitric oxide modulates the catalytic activity of myeloperoxidase.},
  author={H. Abu-Soud and S. Hazen},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 8},
  pages={
          5425-30
        }
}
Myeloperoxidase (MPO), an abundant protein in neutrophils, monocytes, and subpopulations of tissue macrophages, is believed to play a critical role in host defenses and inflammatory tissue injury. To perform these functions, an array of diffusible radicals and reactive oxidant species may be formed through oxidation reactions catalyzed at the heme center of the enzyme. Myeloperoxidase and inducible nitric-oxide synthase are both stored in and secreted from the primary granules of activated… Expand
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