Nitric oxide modulates interleukin-1beta and tumor necrosis factor-alpha synthesis by alveolar macrophages in pulmonary tuberculosis.

@article{Kuo2000NitricOM,
  title={Nitric oxide modulates interleukin-1beta and tumor necrosis factor-alpha synthesis by alveolar macrophages in pulmonary tuberculosis.},
  author={H P Kuo and Chun-Hua Wang and K. S. Huang and Hsin-Yi Lin and C. T. Yu and Catherine Y.-Y. Liu and Lingeng Lu},
  journal={American journal of respiratory and critical care medicine},
  year={2000},
  volume={161 1},
  pages={192-9}
}
Interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha released from alveolar macrophages (AM) in pulmonary tuberculosis (TB) are important in host defense against mycobacterial infection. Nitric oxide (NO) production is enhanced in AM of TB patients. We examined whether NO was implicated in (IL)-1beta and TNF-alpha synthesis by AM of TB patients. Purified AM were retrieved by bronchoalveolar lavage from 11 TB patients and 10 normal subjects, and were cultured with or without the NO… CONTINUE READING
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