Nitric oxide modulates Ca(2+) channels in dorsal root ganglion neurons innervating rat urinary bladder.

@article{Yoshimura2001NitricOM,
  title={Nitric oxide modulates Ca(2+) channels in dorsal root ganglion neurons innervating rat urinary bladder.},
  author={Naoki Yoshimura and Sumihiko Seki and William Chet de Groat},
  journal={Journal of neurophysiology},
  year={2001},
  volume={86 1},
  pages={304-11}
}
The effect of a nitric oxide (NO) donor on high-voltage-activated Ca(2+) channel currents (I(Ca)) was examined using the whole cell patch-clamp technique in L(6)-S(1) dorsal root ganglion (DRG) neurons innervating the urinary bladder. The neurons were labeled by axonal transport of a fluorescent dye, Fast Blue, injected into the bladder wall. Approximately 70% of bladder afferent neurons exhibited tetrodotoxin (TTX)-resistant action potentials (APs), and 93% of these neurons were sensitive to… CONTINUE READING
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