Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation.

@article{Gao2002NitricOM,
  title={Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation.},
  author={Feng Gao and Erhe Gao and Tianli Yue and Eliot H. Ohlstein and Bernard L. Lopez and Theodore A. Christopher and Xin-liang Ma},
  journal={Circulation},
  year={2002},
  volume={105 12},
  pages={1497-502}
}
BACKGROUND Recent evidence from cultured endothelial cell studies suggests that phosphorylation of endothelial nitric oxide synthase (eNOS) through the PI3-kinase-Akt pathway increases NO production. This study was designed to elucidate the signaling pathway involved in the antiapoptotic effect of insulin in vivo and to test the hypothesis that phosphorylation of eNOS by insulin may participate in the cardioprotective effect of insulin after myocardial ischemia and reperfusion. METHODS AND… CONTINUE READING
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