Nitric oxide mediates intestinal pathology but not immune expulsion during Trichinella spiralis infection in mice.

@article{Lawrence2000NitricOM,
  title={Nitric oxide mediates intestinal pathology but not immune expulsion during Trichinella spiralis infection in mice.},
  author={Catherine Elizabeth Lawrence and Jennifer C. Paterson and Xiao-Qing Wei and Foo Yew Eddy Liew and Paul G. Garside and Malcolm W Kennedy},
  journal={Journal of immunology},
  year={2000},
  volume={164 8},
  pages={
          4229-34
        }
}
The relationship between intestinal pathology and immune expulsion of gastrointestinal (GI) nematodes remains controversial. Although immune expulsion of GI helminth parasites is usually associated with Th2 responses, the effector mechanisms directly responsible for parasite loss have not been identified. We have previously shown that while the intestinal pathology accompanying the expulsion of the GI parasite Trichinella spiralis may be dependent on IL-4 and mediated by TNF, parasite loss is… CONTINUE READING
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