Nitric oxide mediates hepatic cytochrome P450 dysfunction induced by endotoxin.

  title={Nitric oxide mediates hepatic cytochrome P450 dysfunction induced by endotoxin.},
  author={Cathy M. Mueller and Annette Scierka and Richard L. Stiller and Yong Man Kim and Daniel R Cook and Jack R. Lancaster and Charles W. Buffington and Wynell Watkins},
  volume={84 6},
BACKGROUND Animals subjected to immunostimulatory conditions (sepsis) exhibit decreased total cytochrome P450 content and decreased P450-dependent drug metabolism. Cytochrome P450 function is of clinical significance because it mediates the metabolism of some opioid and hypnotic drugs. The authors tested the hypothesis that reduced P450 function and decreased drug metabolism in sepsis are mediated by endotoxin-enhanced synthesis of nitric oxide. METHODS Hepatic microsomes were prepared from… CONTINUE READING


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