Nitric oxide mediates a therapeutic effect of nicotine in ulcerative colitis

@article{Green2000NitricOM,
  title={Nitric oxide mediates a therapeutic effect of nicotine in ulcerative colitis},
  author={John T Green and C. E. Richardson and R. W. Marshall and Jonathan Rhodes and H. C. Mckirdy and Gareth A. O. Thomas and G. T. Williams},
  journal={Alimentary Pharmacology \& Therapeutics},
  year={2000},
  volume={14}
}
Ulcerative colitis is a condition of nonsmokers in which nicotine is of therapeutic benefit. 
Transdermal Nicotine as a Treatment Option for Ulcerative Colitis: A Review
TLDR
It was found that transdermal nicotine in combination with conventional therapy was more beneficial than individual treatment with either and further controlled studies evaluating the appropriate dosage for remission and maintenance treatment needs to be done. Expand
Impaired capsaicin and neurokinin‐evoked colonic motility in inflammatory bowel disease
TLDR
Comparing neuromuscular function in normal and IBD‐affected colon in vitro was compared, with emphasis on inhibitory enteric nerves, sensory neuropeptides and stimulation of axon collaterals. Expand
Reply—nicotine‐induced NO release in colitis
TLDR
Green's densings takes a step forward in the understanding of the mechanism of action of nicotine in ulcerative colitis, but there is still a long way to go if considering the long-term effects of nicotine therapy. Expand
Mechanisms of Disease: nicotine—a review of its actions in the context of gastrointestinal disease
TLDR
The actions of nicotine are complex; it is likely that its effects on the central nervous system, gastrointestinal tract and immune system interact with other risk factors, such as genetic susceptibility, to influence disease outcomes. Expand
Differential effect of nitric oxide synthase inhibition on sigmoid colon longitudinal and circular muscle responses to nicotine and nerve stimulation in vitro
Nicotine has been shown to release nitric oxide from nerves in human sigmoid colon. This effect has been used to investigate the innervation and functional relationship of the longitudinal andExpand
Smoking in inflammatory bowel diseases: good, bad or ugly?
TLDR
The role of smoking in inflammatory bowel diseases is reviewed, finding that smoking cessation aggravates ulcerative colitis and improves CD, and smoking increases the risk of developing CD and worsens its course, increasing the need for steroids, immunosuppressants and re-operations. Expand
The pharmacological actions of nicotine on the gastrointestinal tract.
  • W. Wu, C. Cho
  • Medicine
  • Journal of pharmacological sciences
  • 2004
TLDR
Findings of clinical trials give promising results on the use of nicotine as an adjuvant therapy for UC and the beneficial effect of nicotine on UC seems to be mediated through multiple mechanisms. Expand
Effect of smoking and transdermal nicotine on colonic nicotinic acetylcholine receptors in ulcerative colitis.
TLDR
The presence of nA ChRs in colonic epithelium may be pertinent to the beneficial effect of nicotine in UC, but since neither smoking nor nicotine treatment is associated with any change in the expression of epithelial alpha3 nAChRs, the effect may be due to functional changes in the receptor. Expand
Medical treatment of ulcerative colitis.
TLDR
The efficacy, optimal usage, and adverse events profile of agents such as 5-aminosalicylates, corticosteroids, azathioprine, and cyclosporine will be discussed and an algorithm for their use will be developed. Expand
Cigarette smoking and inflammation revisited
TLDR
The effects of smoking on various inflammatory pathologies will be discussed, focusing on oral diseases, airway inflammation, chronic obstructive pulmonary disease (COPD) and inflammatory bowel diseases (IBD), with emphasis on the nuclear factor kappa B (NF-kB) pathway. Expand
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References

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Nicotine enemas for active ulcerative colitis—a pilot study
Since transdermal nicotine is of value in the treatment of active ulcerative colitis but is often associated with side‐effects, an alternative in the form of topical therapy with nicotine enemas hasExpand
Greatly increased luminal nitric oxide in ulcerative colitis
TLDR
A role for nitric oxide in ulcerative colitis has been suggested and luminal NO is rapidly and easily measurable and may be used to monitor inflammatory bowel disease. Expand
Increased nitric oxide synthesis in ulcerative colitis
TLDR
Findings suggest that mucosal NO biosynthesis is increased in active colitis and that NO may have a pathogenic role in ulcerative colitis. Expand
MEDIATORS OF NICOTINE‐INDUCED RELAXATIONS OF THE RAT GASTRIC FUNDUS
TLDR
Relaxations of strips of rat gastric fundus were elicited with nicotine, nitric oxide, NO, sodium nitroprusside, SNP, and vasoactive intestinal polypeptide to study the effects of these drugs on intestinal motility and constipation. Expand
Distribution of inducible nitric oxide synthase in ulcerative colitis.
TLDR
No in colonic mucosa may play a potential role in the pathogenesis of UC, and iNOS expression in colon mucosa was virtually absent during the inactive stage of UC and within the colon of patients with non-UC colitis. Expand
Role of Nitric Oxide in the Colon of Patients with Ulcerative Colitis
TLDR
It is suggested that NANC inhibitory nerves play an important role in the impaired motility observed in patients with UC and that NO plays anImportant role as a neurotransmitter in NANC inhibitsory nerves of human colon. Expand
Transdermal nicotine for active ulcerative colitis.
TLDR
The addition of transdermal nicotine to conventional maintenance therapy improves symptoms in patients with ulcerative colitis. Expand
A meta-analysis of the role of smoking in inflammatory bowel disease
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TLDR
There is no justification for health care providers to change the Surgeon General's recommendations on smoking or tobacco use for ulcerative colitis patients specifically and a review of the literature, meta-analysis of selected studies, and assessment of causality criterion suggest that not smoking and ulceratives colitis and smoking and Crohn's disease are consistent with a causal relationship. Expand
A meta-analysis of the role of smoking in inflammatory bowel disease
TLDR
There is no justification for health care providers to change the Surgeon General's recommendations on smoking or tobacco use for ulcerative colitis patients specifically and a review of the literature, meta-analysis of selected studies, and assessment of causality criterion suggest that not smoking and ulceratives colitis and smoking and Crohn's disease are consistent with a causal relationship. Expand
Nitric oxide synthase activity in ulcerative colitis and Crohn's disease
TLDR
Induction of colonic NO synthase may be involved in the mucosal vasodilation and increased vascular permeability of active ulcerative colitis, and could also contribute to the impaired motility that accompanies toxic dilation. Expand
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