Nitric oxide mediates TNF-α-induced apoptosis in the auditory cell line.

@article{Park2012NitricOM,
  title={Nitric oxide mediates TNF-α-induced apoptosis in the auditory cell line.},
  author={Hun Yi Park and Mi Hye Lee and Sung Un Kang and Hye Sook Hwang and Keehyun Park and Yun-Hoon Choung and Chul-Ho Kim},
  journal={The Laryngoscope},
  year={2012},
  volume={122 10},
  pages={2256-64}
}
OBJECTIVES/HYPOTHESIS Tumor necrosis factor-alpha (TNF-α) is released in a variety of pathological states in the inner ear. Inducible nitric oxide synthase (iNOS) can be induced by cytokines and other inflammatory factors, and is generally thought to be associated with inflammation and other pathological processes in the cochlea. The purpose of the present study was to reveal that TNF-α could induce apoptosis in the auditory cell line and to investigate the role of nitric oxide (NO) in TNF… CONTINUE READING
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