Nitric oxide-mediated regulation of connexin43 expression and gap junctional intercellular communication in mesangial cells.

@article{Yao2005NitricOR,
  title={Nitric oxide-mediated regulation of connexin43 expression and gap junctional intercellular communication in mesangial cells.},
  author={Jian Yao and Nobuhiko Hiramatsu and Ying Zhu and Tetsuo Morioka and Masayuki Takeda and Takashi Oite and Masanori Kitamura},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2005},
  volume={16 1},
  pages={58-67}
}
This study investigated a potential role of nitric oxide (NO) in the regulation of gap junctional intercellular communication (GJIC). Incubation of mesangial cells (MC) with NO donor S-nitroso-N-acetylpenicillamine (SNAP) enhanced both basal and 8-bromo-cAMP-stimulated GJIC as well as expression of gap junction protein connexin43 (Cx43). This potentiating… CONTINUE READING