Nitric oxide-mediated protection of endothelial cells from hydrogen peroxide is mediated by intracellular zinc and glutathione.

@article{CorteseKrott2009NitricOP,
  title={Nitric oxide-mediated protection of endothelial cells from hydrogen peroxide is mediated by intracellular zinc and glutathione.},
  author={Miriam M Cortese-Krott and Christoph Viktor Suschek and Wiebke Wetzel and K D Kr{\"o}ncke and Victoria Kolb-Bachofen},
  journal={American journal of physiology. Cell physiology},
  year={2009},
  volume={296 4},
  pages={C811-20}
}
Oxidative stress may cause endothelial dysfunction and vascular disease. It has been shown that NO protects endothelial cells (EC) against H(2)O(2)-induced toxicity. In addition, it is known that NO within cells induces a zinc release from proteins containing zinc-sulfur complexes. The aim of this study was to investigate whether zinc released intracellularly by NO plays a signaling role in the NO-mediated protection against H(2)O(2) in rat aortic EC. Our results show that the NO-mediated… CONTINUE READING