Nitric oxide-mediated neurogenic vasodilatation in isolated monkey lingual arteries.

@article{Toda1997NitricON,
  title={Nitric oxide-mediated neurogenic vasodilatation in isolated monkey lingual arteries.},
  author={Noboru Toda and Kazuhide Ayajiki and Masanori Uchiyama and Tomio Okamura},
  journal={The American journal of physiology},
  year={1997},
  volume={272 4 Pt 2},
  pages={H1582-8}
}
In isolated monkey lingual arteries denuded of the endothelium and contracted with prostaglandin F2alpha, transmural electrical stimulation produced a contraction that was reduced by prazosin and reversed to a relaxation by additional treatment with alpha,beta-methylene ATP. The relaxation thus induced was abolished by tetrodotoxin and N(G)-nitro-L-arginine (L-NNA), a nitric oxide (NO) synthase inhibitor, and L- but not D-arginine restored the response in the L-NNA-treated arteries. Under… CONTINUE READING
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