Nitric oxide-mediated mitochondrial damage: a potential neuroprotective role for glutathione.

@article{Bolaos1996NitricOM,
  title={Nitric oxide-mediated mitochondrial damage: a potential neuroprotective role for glutathione.},
  author={Juan P Bola{\~n}os and Simon J. R. Heales and S Peuchen and J. Ellis Barker and John M. Land and John Bates Clark},
  journal={Free radical biology & medicine},
  year={1996},
  volume={21 7},
  pages={995-1001}
}
In this study we have investigated the mechanisms leading to mitochondrial damage in cultured neurons following sustained exposure to nitric oxide. Thus, the effects upon neuronal mitochondrial respiratory chain complex activity and reduced glutathione concentration following exposure to either the nitric oxide donor, S-nitroso-N-acetylpenicillamine, or to… CONTINUE READING