Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes.

@article{Bolaos1994NitricOI,
  title={Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes.},
  author={Juan P Bola{\~n}os and S Peuchen and Simon J. R. Heales and John M. Land and John Bates Clark},
  journal={Journal of neurochemistry},
  year={1994},
  volume={63 3},
  pages={910-6}
}
The Ca(2+)-independent form of nitric oxide synthase was induced in rat neonatal astrocytes in primary culture by incubation with lipopolysaccharide (1 microgram/ml) plus interferon-gamma (100 U/ml), and the activities of the mitochondrial respiratory chain components were assessed. Incubation for 18 h produced 25% inhibition of cytochrome c oxidase activity. NADH-ubiquinone-1 reductase (complex I) and succinate-cytochrome c reductase (complex II-III) activities were not affected. Prolonged… CONTINUE READING

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