Nitric oxide-mediated inhibition of NFkappaB regulates hyperthermia-induced apoptosis.

@article{Aravindan2009NitricOI,
  title={Nitric oxide-mediated inhibition of NFkappaB regulates hyperthermia-induced apoptosis.},
  author={Natarajan Aravindan and Sumathy Mohan and Terence S. Herman and Mohan Natarajan},
  journal={Journal of cellular biochemistry},
  year={2009},
  volume={106 6},
  pages={
          999-1009
        }
}
Ascertaining the upstream regulatory mechanisms of hyperthermia-induced apoptosis is important to understand the role of hyperthermia in combined modality cancer therapy. Accordingly, we investigated whether (i) hyperthermia-induced apoptosis is mediated through the nitric oxide (NO) signaling pathway and (ii) inhibition of post-translational modification of IkappaBalpha and down regulation of NFkappaB-DNA binding activity is an intermediate step in NO-dependent apoptosis in MCF-7 breast cancer… CONTINUE READING