Nitric-oxide mediated effects of transdermal capsaicin patches on the ischemic threshold in patients with stable coronary disease.

@article{Fragasso2004NitricoxideME,
  title={Nitric-oxide mediated effects of transdermal capsaicin patches on the ischemic threshold in patients with stable coronary disease.},
  author={Gabriele Fragasso and Altin Palloshi and Pier Marco Piatti and Lucilla Monti and Enrico Rossetti and Emanuela Setola and Chiara Montano and Giorgio Bassanelli and Giliola Calori and Alberto Margonato},
  journal={Journal of cardiovascular pharmacology},
  year={2004},
  volume={44 3},
  pages={
          340-7
        }
}
BACKGROUND Capsaicin has been shown to exert direct vasodilating effects through increased calcitonin gene-related peptide (CGRP) release. However, no data exist on its effect following systemic administration in humans. METHODS Twelve male patients with stable coronary disease and a persistently positive exercise were selected for study. According to a double blind, placebo-controlled, cross-over study, patients were randomized to placebo or 3 g oleic capsaicin-containing patches, on 2… CONTINUE READING
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