Nitric-oxide-mediated activation of iron-regulatory protein controls hepatic iron metabolism during acute inflammation.

@article{Cairo1995NitricoxidemediatedAO,
  title={Nitric-oxide-mediated activation of iron-regulatory protein controls hepatic iron metabolism during acute inflammation.},
  author={Gaetano Cairo and Antonello Pietrangelo},
  journal={European journal of biochemistry},
  year={1995},
  volume={232 2},
  pages={358-63}
}
The molecular regulation of intracellular iron metabolism has been studied in the livers of rats undergoing an acute inflammatory reaction following turpentine injection. Treatment induced an increase in the steady-state level of the transferrin receptor (TfR) mRNA, peaking 18 h after treatment and returning to control levels 24 h after treatment, with no change in TfR gene transcription. RNA band-shift assays documented an activation of the cytoplasmic RNA-binding protein called the iron… CONTINUE READING

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