Nitric oxide may inhibit neointimal hyperplasia by decreasing isopeptidase T levels and activity in the vasculature.

@article{Tsihlis2013NitricOM,
  title={Nitric oxide may inhibit neointimal hyperplasia by decreasing isopeptidase T levels and activity in the vasculature.},
  author={Nick D Tsihlis and Muneera Kapadia and Ashley K. Vavra and Walker D. Flannery and C. S. Oustwani and Q. Jiang and M. Kibbe},
  journal={Journal of vascular surgery},
  year={2013},
  volume={58 1},
  pages={
          179-86
        }
}
OBJECTIVE Isopeptidase T is a cysteine protease deubiquitinating enzyme that hydrolyzes unanchored polyubiquitin chains to free monoubiquitin. Nitric oxide (NO) decreases 26S proteasome activity in vascular smooth muscle cells (VSMCs) and inhibits neointimal hyperplasia in animal models. As NO can cause S-nitrosylation of active-site cysteines, we hypothesize that NO inhibits isopeptidase T activity through S-nitrosylation. Because accumulation of polyubiquitin chains inhibits the 26S… Expand
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