Nitric oxide isoenzymes regulate lipopolysaccharide-enhanced insulin transport across the blood-brain barrier.

@article{Banks2008NitricOI,
  title={Nitric oxide isoenzymes regulate lipopolysaccharide-enhanced insulin transport across the blood-brain barrier.},
  author={W. A. Banks and Shinya Dohgu and Jessica L. Lynch and Melissa A. Fleegal-Demotta and Michelle A. Erickson and Ryota Nakaoke and Than Q Vo},
  journal={Endocrinology},
  year={2008},
  volume={149 4},
  pages={1514-23}
}
Insulin transported across the blood-brain barrier (BBB) has many effects within the central nervous system. Insulin transport is not static but altered by obesity and inflammation. Lipopolysaccharide (LPS), derived from the cell walls of Gram-negative bacteria, enhances insulin transport across the BBB but also releases nitric oxide (NO), which opposes LPS-enhanced insulin transport. Here we determined the role of NO synthase (NOS) in mediating the effects of LPS on insulin BBB transport. The… CONTINUE READING
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