Nitric oxide is a regulator of hematopoietic stem cell activity.

  title={Nitric oxide is a regulator of hematopoietic stem cell activity.},
  author={Tatyana V Michurina and Peter Krasnov and Alejandro B. Balazs and Naoki Nakaya and Tamara V. Vasilieva and Boris Kuzin and Nikolay Khrushchov and Richard C. Mulligan and Grigori Enikolopov},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  volume={10 2},
Hematopoietic stem cells give rise to various multipotent progenitor populations, which expand in response to cytokines and which ultimately generate all of the elements of the blood. Here we show that it is possible to increase the number of stem and progenitor cells in the bone marrow (BM) by suppressing the activity of NO synthases (NOS). Exposure of mice to NOS inhibitors, either directly or after irradiation and BM transplantation, increases the number of stem cells in the BM. In the… CONTINUE READING


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