Nitric oxide involvement in the antidepressant-like effects of acute lithium administration in the mouse forced swimming test

  title={Nitric oxide involvement in the antidepressant-like effects of acute lithium administration in the mouse forced swimming test},
  author={Mehdi Ghasemi and Hamed Sadeghipour and Afsaneh Mosleh and Hamid Reza Sadeghipour and Ali R. Mani and Ahmad Reza Dehpour},
  journal={European Neuropsychopharmacology},
NMDA receptor/nitrergic system blockage augments antidepressant-like effects of paroxetine in the mouse forced swimming test
It is suggested, for the first time, a possible role for NMDAR/NO signaling in the antidepressant-like effects of paroxetine, providing a new approach for the treatment of depression.
Involvement of NO/cGMP pathway in the antidepressant-like effect of gabapentin in mouse forced swimming test
The results indicate that the antidepressant-like effect of gabapentin in the mice FST model is mediated at least in part through nitric oxide/cyclic guanosine monophosphate (cGMP) pathway.


Antidepressant-like effect of 7-nitroindazole in the forced swimming test in rats
The findings suggest that NO might be an important modulator of depression in rats, as well as a test for screening new antidepressant agents.
Systemic Administration of Nω-Nitro-l-Arginine Methyl Ester and Indomethacin Reduces the Elevation of Brain PGE2Content and Prevents Seizures and Hippocampal Damage Evoked by LiCl and Tacrine in Rat
Indomethacin (10 mg/kg given i.p. 30 min before tacrine), an inhibitor of COX activity, prevented brain PGE2 elevation and abolished the expression of seizures and hippocampal damage thus supporting a role for this metabolite of the arachidonic acid cascade in the mechanisms of LiCl and tacrine-evoked neurotoxicity in rat.
Combined chronic treatment with citalopram and lithium does not modify the regional neurochemistry of nitric oxide in rat brain.
  • G. Wegener, Z. Bandpey, B. Harvey
  • Biology, Psychology
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
  • 2004
It is concluded that basal conditions are unsuitable for the study of antidepressant effects on NOS, and that the neurochemistry of nitric oxide remains unaltered following chronic citalopram or subchronic lithium under normal physiological conditions.
Additive effects of lithium and antidepressants in the forced swimming test: further evidence for involvement of the serotoninergic system
The hypothesis that the potentiation by lithium of ADS is via direct 5HT mechanisms, indirect via a NA/5HT link, and/or by second messenger systems is supported.
Evidence that lithium induces a glutamatergic: Nitric oxide-mediated response in rat brain
Data implicate an involvement of a glutamatergic-mediated NO:cGMP transduction mechanism in the action of Li+.