Nitric oxide inhibits the formation of advanced glycation end products.

  title={Nitric oxide inhibits the formation of advanced glycation end products.},
  author={Kayoko Asahi and Kohji Ichimori and Hayakazu Nakazawa and Yuko Izuhara and Reiko Inagi and Tomomi Watanabe and Toshio Miyata and Kiyoshi Kurokawa},
  journal={Kidney international},
  volume={58 4},
BACKGROUND Advanced glycation end products (AGEs) are elevated in renal failure and have been implicated in the pathogenesis of several uremic complications. Their formation is closely associated with oxidative stress. The recent observation that nitric oxide (NO) has an antioxidant effect led us to examine the possible role of NO in the generation of AGEs. METHODS We examined the effect of NO donors, 2, 2'-(hydroxynitrosohydrazono)bis-ethanamine (NOC18) and S-nitroso-N-acetyl-DL… CONTINUE READING


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