Nitric oxide inhibits stretch-induced MAPK activation in mesangial cells through RhoA inactivation.

@article{Krepinsky2003NitricOI,
  title={Nitric oxide inhibits stretch-induced MAPK activation in mesangial cells through RhoA inactivation.},
  author={Joan C Krepinsky and Alistair J. Ingram and Damu Tang and Dongcheng Wu and Lieqi Liu and James William Scholey},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2003},
  volume={14 11},
  pages={2790-800}
}
Glomerular capillary hypertension is an important determinant of glomerulosclerosis in rats with subtotal renal ablation. Dietary supplementation with L-arginine increases renal nitric oxide (NO) production and limits glomerular injury in this model, and early benefits are seen without altered glomerular capillary pressure. In an in vitro model of hemodynamically mediated signaling, the authors have reported that subjecting MC to cyclic stretch/relaxation activates the mitogen-activated protein… CONTINUE READING

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