Nitric oxide inhibits hypothalamic luteinizing hormone-releasing hormone release by releasing gamma-aminobutyric acid.

  title={Nitric oxide inhibits hypothalamic luteinizing hormone-releasing hormone release by releasing gamma-aminobutyric acid.},
  author={Adriana Seilicovich and Beatriz Hayd{\'e}e Duvilanski and Daniel Pisera and Susana Theas and Martha F. Gimeno and Val{\'e}ria Rettori and Samuel M. Mccann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  pages={3421 - 3424}
Nitric oxide synthase (NOS)-containing neurons, termed NOergic neurons, occur in various regions of the hypothalamus, including the median eminence-arcuate region, which plays an important role in controlling the release of luteinzing hormone-releasing hormone (LHRH). We examined the effect of NO on release of gamma-aminobutyric acid (GABA) from medial basal hypothalamic (MBH) explants incubated in vitro. Sodium nitroprusside (NP) (300 microM), a spontaneous releaser of NO, doubled the release… 
Nitric oxide inhibits the release of norepinephrine and dopamine from the medial basal hypothalamus of the rat.
The results indicate that NO acts to suppress release of both amines, which may be an important means for terminating the pulses of release of LHRH, which generate the pulsatile release of LH that stimulates gonadal function in both male and female mammals.
beta-Endorphin blocks luteinizing hormone-releasing hormone release by inhibiting the nitricoxidergic pathway controlling its release.
Results indicate that beta-endorphin stimulates mu-opioid receptors on NOergic neurons to inhibit the activation and consequent synthesis of NOS in the MBH.
Inhibitory pathways and the inhibition of luteinizing hormone-releasing hormone release by alcohol.
The mechanisms by which ethanol (EtOH) inhibits luteinizing hormone-releasing hormone (LHRH) release from incubated medial basal hypothalamic explants were examined, finding that the action of alcohol can be accounted for by stimulation of beta-endorphin neurons that inhibit LHRH release by inhibition of activation of NOS and stimulation of GABA release.
Role of Nitric Oxide and Alcohol on Gonadotropin Release in Vitro and in Vivoa
The results support the theory that NE acts to stimulate NO release from NOergic neurons, and indicate that alcohol suppresses LHRH release, at least in part, by stimulating β‐endorphinergic neurons that inhibit the release of NE, which drives the NOergic release of L HRH.
Role of Nitric Oxide/Cyclic GMP Pathway in the Inhibitory Effect of GABA and Dopamine on Prolactin Release
No seems to be involved in the inhibitory effect of GABA on prolactin release since hemoglobin, a scavenger of NO, and Nw‐nitro‐L‐arginine methyl ester, an inhibitor of NO synthase (NOS), blocked the pituitary response to GABA.
Alcohol inhibits luteinizing hormone-releasing hormone release by activating the endocannabinoid system.
EtOH inhibits the release of LHRH acting through the endocannabinoid system, and whether CB1-r is involved in the inhibition of L HRH by EtOH and AEA is investigated.
The role of nitric oxide in the control of basal and LHRH-stimulated LH secretion
Evidence is provided that the global action of NOS inhibitors is an increase in basal LH secretion, through a mechanism that remains to be fully characterized.
Acute effect of manganese on hypothalamic luteinizing hormone releasing hormone secretion in adult male rats: involvement of specific neurotransmitter systems.
It is suggested that the additional action of MnCl2 to release GABA, a LHRH inhibitor, may ultimately contribute to suppressed reproductive function observed in adult animals following exposure to high chromic levels of Mn+2.
Effects of Systemic Blockade of Nitric Oxide Synthases on Pulsatile LH, Prolactin, and GH Secretion in Adult Male Rats
The data strongly suggest that the stimulatory effect of NAME on LH secretion is not due to an inhibition of testosterone release and is exerted at the hypothalamic-pituitary level.