Nitric oxide inhibits hypothalamic luteinizing hormone-releasing hormone release by releasing gamma-aminobutyric acid.

@article{Seilicovich1995NitricOI,
  title={Nitric oxide inhibits hypothalamic luteinizing hormone-releasing hormone release by releasing gamma-aminobutyric acid.},
  author={Adriana Seilicovich and Beatriz Hayd{\'e}e Duvilanski and Daniel Pisera and Susana Theas and Martha F. Gimeno and Val{\'e}ria Rettori and Samuel M. Mccann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92},
  pages={3421 - 3424}
}
Nitric oxide synthase (NOS)-containing neurons, termed NOergic neurons, occur in various regions of the hypothalamus, including the median eminence-arcuate region, which plays an important role in controlling the release of luteinzing hormone-releasing hormone (LHRH). We examined the effect of NO on release of gamma-aminobutyric acid (GABA) from medial basal hypothalamic (MBH) explants incubated in vitro. Sodium nitroprusside (NP) (300 microM), a spontaneous releaser of NO, doubled the release… 
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